Engineers at the University of Pennsylvania have built a lipid nanoparticle that chemically fuses an IDO-pathway inhibitor with the very lipids that carry IL-12 mRNA into tumors, creating a single ...

Engineers at the University of Pennsylvania have developed a new type of lipid nanoparticle (LNP) that could one day serve as a universal immunotherapy for cancers that form solid tumors, including ...

T cells are supposed to be relentless. These white blood cells patrol the body, identify threats, and destroy them.

Lipid nanoparticle formulation has increased over the past two decades. LNPs have proven to be effective nano-based delivery vehicles for cytotoxic chemotherapeutic drugs, nucleic acid therapies and ...

Lipid-based nanoparticles are a popular research area as a non-viral platform for delivering RNA molecules and include liposomes, lipoplexes, lipid nanoparticles and solid lipid nanoparticles. Using ...

Researchers in Brazil have reported that ferroin, an iron complex delivered by lipid nanoparticles, eliminates detectable Mycobacterium tuberculosis from mouse lungs after 30 days, suggesting a ...

ATLANTA—An oral lipid nanoparticle drug prevents tumor development in mice, suggesting this is a promising drug formulation for preventing colitis-associated cancer, according to a study led by ...

An oral lipid nanoparticle drug prevents tumor development in mice, suggesting this is a promising drug formulation for preventing colitis-associated cancer, according to a study led by researchers in ...

LNPs consist of ionizable lipids, which are critical for encapsulating RNA and enabling cellular uptake. Helper lipids contribute to the structural integrity and fusion with cell membranes.