For decades, scientists have recognized that human immunodeficiency virus (HIV) is a formidable viral pathogen. After years of probing work and extensive experimentation, a Yale research team has ...

The re-transcribed DNA is then integrated into the genome of the host cell (Figure 2). This process requires the absence of the nuclear membrane and thus is restricted to the M-phase of proliferating ...

A research team at the University of Würzburg has deciphered another aspect of poxviral gene activation. They have revealed a unique viral mechanism: A molecular ring anchors the viral copying machine ...

We have examined the effect of ribavirin on vesicular stomatitis virus (VSV) RNA synthesis using a cell-free transcription system. Our prior data indicated that ribavirin had little effect on primary ...

Schematic representation of histone-modifying factor recruitment on cccDNA minichromosomes in relation to viral protein HBx. In the presence of HBx, histone-modifying factors such as p300/CBP, Set1A, ...

Ongoing research aims to confirm the mechanism by which ICP4 fluidizes the nucleus, which could indicate specific targets to counter viral replication.

The technology, called the Viral-Engineered RNA-based Activation System (VERAS), hijacks the virus’s own replication machinery to switch on reporter or therapeutic genes precisely in infected cells.