What is a cytokine storm and how can it kill you? CGTN Europe’s RAZOR speak to Jonathan Lacey, who explains how an overreaction of the immune system can be fatal to COVID-19 sufferers. #COVID19 #coronavirus | CGTNEurope
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Sepsis/shock unleash DAMPs/PAMPs, triggering a cytokine storm (SIRS) that causes endothelial damage, microvascular thrombosis, and hypoperfusion. This culminates in multi-organ dysfunction: neurologic (encephalopathy), respiratory (ARDS), cardiovascular (vasoplegia, myocardial depression), AKI, hepatic dysfunction, GI ileus/translocation, and coagulopathy. Early, aggressive intervention is critical. Ref: Mosier et al. J Trauma Acute Care Surg. 2024;97(6). #Sepsis #MOF #CriticalCare #MedEd | Abda
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